Tg2 Review

Often referred to as tissue transglutaminase, TG2 is a multifunctional, Ca²⁺-dependent protein that acts far beyond a simple crosslinker. It’s an enzyme that wears many hats:

When things go wrong, TG2 shifts roles. In the extracellular space, it binds to integrins and acts as a co-receptor, facilitating cell adhesion and migration. Often referred to as tissue transglutaminase, TG2 is

TG2 acts as a "molecular glue," crosslinking extracellular collagen and fibronectin to help stabilize tissue structure, making it vital for wound healing. Often referred to as tissue transglutaminase