: After Derek and Bailey discover that Izzie has an inoperable brain tumor, the group decides to celebrate her life and love immediately.
: George O'Malley faces an emotional crisis when almost all the students from the accident die under his care, leaving him devastated until Owen Hunt helps him see the lives he did save. [S5E22] What a Difference a Day Makes
: Despite the shift in plans, the wedding remains a fan favorite, featuring the original "MAGIC" interns (Meredith, Alex, George, Izzie, and Cristina) as the wedding party. : After Derek and Bailey discover that Izzie
: Creator Shonda Rhimes noted that Denny's appearance in this episode was meant to represent "Death," which is why he wore black and spoke sparingly compared to previous appearances. the wedding remains a fan favorite