A completely free, browser-based tool that provides the Python source code for every figure you create, ensuring your work is reproducible.
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A free and open-source "community-driven" statistical spreadsheet that is very user-friendly and built on top of the R statistical language.
If you are currently enrolled in a university, you can often get a heavily discounted student license for about $100–$150 per year.
If Prism isn't an option, these free tools can produce publication-quality results: