Many mods require a version of F4SE that matches your game version exactly. If your game is v1.10.50, you must ensure you have the legacy F4SE version designed for that build, or many advanced mods will fail to launch.
This specific version of Fallout 4 was a notable update released by Bethesda to address specific bugs and stability issues. Fallout.4.v1.10.50.0.Hotfix.Inclu.ALL.DLC.part4...
Large games like Fallout 4 (which can exceed 30–50 GB with all DLCs) are often split into smaller "parts" for easier uploading and downloading. Many mods require a version of F4SE that