Never drink or sell Nuka-Cola or Nuka-Cola Quantum. Save them for the Nuka-Cola Challenge quest later.
Take Comprehension . This doubles the skill points you receive from reading found skill books. fallout-3-game-of-the-year-edition
Leave room for the stat-boosting Bobbleheads scattered across the Capital Wasteland. Never drink or sell Nuka-Cola or Nuka-Cola Quantum
Take Educated . It grants extra skill points every single time you level up. fallout-3-game-of-the-year-edition