Often causing abdominal discomfort or early satiety.
The most frequent type, often associated with a "villous" lymphocyte morphology in blood smears. Download Lymphomes splГ©niques pdf
A provisional category for cases that do not meet the strict criteria for SMZL or SDRPL. 3. Diagnostic Approach Often causing abdominal discomfort or early satiety
Primary splenic lymphomas account for less than 1% of all non-Hodgkin lymphomas (NHL). Unlike nodal lymphomas, these diseases typically present with massive splenomegaly without significant lymphadenopathy. Accurate diagnosis is critical, as treatment varies significantly from other B-cell malignancies. 2. Classification of Splenic B-Cell Lymphomas and molecular data:
Peripheral blood smears often show "villous" lymphocytes (small cells with polar cytoplasmic projections). Immunophenotyping: Flow cytometry typically reveals
While splenectomy was previously the gold standard, bone marrow biopsy (showing intrasinusoidal infiltration) is now a primary diagnostic tool. Genetics: Deletion of
Diagnosis requires a multidisciplinary integration of clinical, morphological, and molecular data: