For players on Windows 10 or 11, the following adjustments are highly recommended to stabilize the game:
Conflicts between the game's renderer and modern display settings can lead to "soft locks" during dialogue: Deus ex human revolution dialogue crash fix
Modern CPUs with many cores can cause the game to fail immediately or during heavy processing tasks. For players on Windows 10 or 11, the
Download the Startup Crash Fix from Nexus Mods to patch the executable for modern processors. Deus ex human revolution dialogue crash fix
Try running the game in Windowed Mode or use a "Borderless Window" tool if the game crashes when Alt-Tabbing or during cinematic-to-dialogue transitions. Known Game Glitches Left dialogue crashes - Deus Ex: Human Revolution
A common cause of freezing is how the game handles internal threading.