: Protein Kinase G Iα (PKG Iα) is usually activated by cGMP, but it can also be activated by "oxidative stress" (specifically the formation of a disulfide bond at Cys42).
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: Measurement of blood pressure in conscious, freely moving mice using telemetric probe catheters . 23484.rar
: To prove that preventing or reversing this oxidative activation can lower blood pressure. 3. Methods (Key Techniques)
: Data demonstrating that novel compounds targeting this site effectively lower blood pressure. 5. Discussion and Conclusion : Protein Kinase G Iα (PKG Iα) is
: Use of C57BL/6 mice and specialized Cys42Ser KI (knock-in) mice that are resistant to PKG oxidative activation.
: Western immunoblotting to detect the redox state of PKG and phosphorylation levels. 4. Results : To prove that preventing or reversing this
: Evidence that oxidant-induced PKG Iα disulfide formation occurs in vivo during hypertension.