22948 Rar Link
: RARA acts as a transcription factor. When it binds to Retinoic Acid (a derivative of Vitamin A), it regulates the expression of genes involved in cell growth, differentiation, and development.
The gene provides instructions for making a protein called the retinoic acid receptor alpha, which is a nuclear receptor critical for various biological processes.
: It is most famous for its role in Acute Promyelocytic Leukemia (APL) . In most cases of APL, a piece of chromosome 15 (containing the PML gene) and a piece of chromosome 17 (containing the RARA gene) swap places. This creates a fusion protein called PML-RARA , which prevents immature white blood cells from maturing properly.
: RARA acts as a transcription factor. When it binds to Retinoic Acid (a derivative of Vitamin A), it regulates the expression of genes involved in cell growth, differentiation, and development.
The gene provides instructions for making a protein called the retinoic acid receptor alpha, which is a nuclear receptor critical for various biological processes.
: It is most famous for its role in Acute Promyelocytic Leukemia (APL) . In most cases of APL, a piece of chromosome 15 (containing the PML gene) and a piece of chromosome 17 (containing the RARA gene) swap places. This creates a fusion protein called PML-RARA , which prevents immature white blood cells from maturing properly.
